Antiviral Activity of Nobiletin against Chikungunya virus in vitro

@article{Lin2017AntiviralAO,
  title={Antiviral Activity of Nobiletin against Chikungunya virus in vitro},
  author={Shih-Chao Lin and Mei-Chun Chen and Shiming Li and Chi-Chen Lin and Tony T. Wang},
  journal={Antiviral Therapy},
  year={2017},
  volume={22},
  pages={689 - 697}
}
Background Chikungunya virus (CHIKV), a highly contagious re-emerging virus, is transmitted by infected mosquitoes. CHIKV is prevalent in tropical countries and is continuing to creep farther north into temperate areas. CHIKV is responsible for induction of chikungunya fever (CF) and severe joint stiffness with the capability of developing into bilateral and systemic arthralgia or even encephalitis. Despite the high morbidity rate, no approved antiviral drug is available. Therefore, an anti… 

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References

SHOWING 1-10 OF 35 REFERENCES

Antiviral activity of selected flavonoids against Chikungunya virus.

Antiviral Strategies Against Chikungunya Virus

The current status of the development of antiviral strategies against CHIKV infections is summarized, which consists of the administration of analgesics, antipyretics, and anti-inflammatory agents.

Chikungunya Virus Infection

The globalization of CHIKV exposes countries with Aedes mosquitoes both to brutal outbreaks of acute incapacitating episodes and endemic long-lasting disorders.

A Pathogenic Role for CD4+ T Cells during Chikungunya Virus Infection in Mice

Observations strongly indicate that mechanisms of joint pathology induced by CHIKV in mice resemble those in humans and differ from infections caused by other arthritogenic viruses, such as Ross River virus.

Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response

It is demonstrated for the first time that CHIKV Ags could be detected in vivo in the monocytes of acutely infected patients, and monocytes could be infected and virus growth could be sustained, and a better understanding on the basic mechanisms of infection and early antiviral immune responses is provided.

Chronic Joint Disease Caused by Persistent Chikungunya Virus Infection Is Controlled by the Adaptive Immune Response

It is suggested that chronic musculoskeletal tissue pathology is caused by persistent Chikungunya virus infection and controlled by adaptive immune responses, and the development of strategies to mitigate the disease burden associated with CHIKV infection in humans.

Chikungunya virus and prospects for a vaccine

The challenges to the development of a safe, effective and affordable chikungunya vaccine are discussed and recent progress toward this goal is discussed.

Chikungunya Virus: In Vitro Response to Combination Therapy With Ribavirin and Interferon Alfa 2a.

These studies illustrate the promise of RBV plus IFN alfa as a potential therapeutic strategy for the treatment of CHIKV infections and validate the prediction made by the mathematical model.

Antiviral activity in tissue culture systems of bis-benzimidazoles, potent inhibitors of rhinoviruses.

(S,S)-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2-ethanediol showed antiviral activity in monolayer tissue culture systems against 55 strains of rhinovirus, three types of poliovirus, and strains of type