Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.

@article{Gabrielsen1992AntiviralA,
  title={Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.},
  author={B C Gabrielsen and Thomas P Monath and John W. Huggins and Deborah F. Kefauver and George R. Pettit and G Groszek and Melinda G. Hollingshead and J J Kirsi and William M. Shannon and Evelyn Schubert},
  journal={Journal of natural products},
  year={1992},
  volume={55 11},
  pages={1569-81}
}
A series of 23 Amaryllidaceae isoquinoline alkaloids and related synthetic analogues were isolated or synthesized and subsequently evaluated in cell culture against the RNA-containing flaviviruses (Japanese encephalitis, yellow fever, and dengue viruses), bunyaviruses (Punta Toro, sandfly fever, and Rift Valley fever viruses), alphavirus (Venezuelan equine encephalomyelitis virus), lentivirus (human immunodeficiency virus-type 1) and the DNA-containing vaccinia virus. Narciclasine [1… CONTINUE READING

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