Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.

@article{Thisse1999AntivinAN,
  title={Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.},
  author={Christine I Thisse and Bernard V Thisse},
  journal={Development},
  year={1999},
  volume={126 2},
  pages={229-40}
}
Mesoderm induction and patterning are mediated by members of the TGFbeta superfamily. We have isolated a novel zebrafish member, antivin, that structurally is highly related to mouse lefty. Overexpression of antivin completely abolishes mesoderm induction at blastula stage, yet resultant embryos develop well-patterned epidermal and neural derivatives. The mesoderm-inhibiting activity of antivin can be mimicked by lefty and is suppressed by increasing levels of the mesodermal inducer Activin or… CONTINUE READING
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Stra 3 / Lefty , a retinoid acidinducible novel member of the transforming growth factorβ family

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