Antivector and antitransgene host responses in gene therapy.

@article{Hackett2000AntivectorAA,
  title={Antivector and antitransgene host responses in gene therapy.},
  author={Neil R. Hackett and S M Kaminsky and D Sondhi and Ronald G. Crystal},
  journal={Current opinion in molecular therapeutics},
  year={2000},
  volume={2 4},
  pages={
          376-82
        }
}
Current viral gene therapy vectors effectively transfer genes in vivo at the price of eliciting innate and acquired host responses against the vector and/or transgene. Antigens present in the viral vector and the expression of the transgene both cause cellular and humoral immune responses dependent on the viral vector, the route of administration, and the genotype and infection history of the host. In general, adenoviral vectors cause strong immune responses, which result in only transient… CONTINUE READING

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