Antiulcer prostaglandin misoprostol: single and multiple dose pharmacokinetic profile.

@article{Karim1987AntiulcerPM,
  title={Antiulcer prostaglandin misoprostol: single and multiple dose pharmacokinetic profile.},
  author={A. Karim},
  journal={Prostaglandins},
  year={1987},
  volume={33 Suppl},
  pages={
          40-50
        }
}
  • A. Karim
  • Published 1987
  • Medicine
  • Prostaglandins
Low misoprostol dose (microgram range), extremely low plasma levels (pg range) of misoprostol acid, and the necessity of using a complex, time consuming, and labor intensive RIA method of analysis make it technically difficult to study the pharmacokinetic profile of misoprostol in man. The clinical relevance of the misoprostol pharmacokinetic data should be interpreted with care in view of the combined local and systemic effects of the drug. The studies presented in the present review indicate… Expand
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