Antitussive effects of naltrindole, a selective delta-opioid receptor antagonist, in mice and rats.

@article{Kamei1993AntitussiveEO,
  title={Antitussive effects of naltrindole, a selective delta-opioid receptor antagonist, in mice and rats.},
  author={Junzo Kamei and Yuriko Iwamoto and Tsutomu Suzuki and Miwa Misawa and Hiroshi Nagase and Yutaka Kasuya},
  journal={European journal of pharmacology},
  year={1993},
  volume={249 2},
  pages={
          161-5
        }
}
The effects of naltrindole, a selective delta-opioid receptor antagonist, on the capsaicin-induced cough reflex in mice and rats were studied. Intraperitoneal administration of naltrindole decreased the number of coughs both in mice and rats dose dependently. The cough-depressant effects reached a peak 15 min after the administration of naltrindole and lasted more than 120 min. Pretreatment with [D-Pen2,D-Pen5]enkephalin, a selective delta-opioid receptor agonist, partially but significantly… CONTINUE READING

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