Antitussive effects of memantine in guinea pigs.


BACKGROUND The treatment of cough is a significant clinical unmet need because there is little evidence that current therapies are effective. Based on evidence supporting a role for N-methyl D-aspartate receptors (NMDARs) in cough, we hypothesized that memantine, a low-affinity, uncompetitive NMDAR channel blocker in routine use for the treatment of… (More)
DOI: 10.1378/chest.11-0554


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