Antitussive effect of K+ channel openers.

  title={Antitussive effect of K+ channel openers.},
  author={R. Poggioli and Augusta Benelli and Rossana Arletti and Elena Cavazzuti and Alfio Bertolini},
  journal={European journal of pharmacology},
  volume={371 1},
The effect of the K(ATP) channel openers, pinacidil and cromakalim, on coughing was studied in guinea pigs exposed to a nebulized aqueous solution of citric acid (0.50 M). Both pinacidil and cromakalim, subcutaneously administered 45 min before the test, inhibited coughing. The D50 (95% CI) were 0.95 +/- 0.90 mg/kg for cromakalim and 3.25 +/- 0.92 mg/kg for pinacidil. Under our experimental conditions, the D50 (95% CI) of codeine was 1.74 +/- 0.75 mg/kg. The combination of cromakalim and… CONTINUE READING