Antitussive Profile of the NOP Agonist Ro-64-6198 in the Guinea Pig

@article{Mcleod2004AntitussivePO,
  title={Antitussive Profile of the NOP Agonist Ro-64-6198 in the Guinea Pig},
  author={Robbie L. Mcleod and Yanlin Jia and Xiomara Fernandez and L. Edgar Parra and Xin Wang and Deen Bandhu Tulshian and Eugenia Kiselgof and Zheng Tan and Ahmad B. Fawzi and April Smith-Torhan and Hongtao Zhang and John A. Hey},
  journal={Pharmacology},
  year={2004},
  volume={71},
  pages={143 - 149}
}
We have previously shown that N/OFQ, the endogenous peptide ligand for the ‘opioid-like’ NOP receptor, inhibits cough in guinea pigs and cats. In the present study we sought to continue our characterization of the cough-suppressant effects of NOP stimulation by profiling the pulmonary and antitussive effects of a novel non-peptide NOP agonist, Ro-64-6198, in guinea pigs. In receptor-binding assays, we confirmed that Ro-64-6198 selectively binds to NOP receptors over other opioid receptors. The… 

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The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity.

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It is concluded that TRPV1 channel activation may play role in cough mediated by antigen in sensitized guinea pigs and supports increasing evidence that TRpV1 may play a role in the generation of the cough response.

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