Antitussive, expectorant, and anti-inflammatory activities of four caffeoylquinic acids isolated from Tussilago farfara

@article{Wu2016AntitussiveEA,
  title={Antitussive, expectorant, and anti-inflammatory activities of four caffeoylquinic acids isolated from Tussilago farfara},
  author={Qi-Zhen Wu and Dong‐Xia Zhao and Juan Xiang and Mian Zhang and Chaofeng Zhang and Xiang-hong Xu},
  journal={Pharmaceutical Biology},
  year={2016},
  volume={54},
  pages={1117 - 1124}
}
Abstract Context: The flower bud of Tussilago farfara L. (Compositae) (FTF) is one of the traditional Chinese medicinal herbs used to treat cough, phlegm, bronchitic, and asthmatic conditions. Objective: The objective of this study is to isolate four caffeoylquinic acids from the ethyl acetate extract (EtE) of FTF and to evaluate their antitussive, expectorant, and anti-inflammatory activities. Materials and methods: The structures of compounds 1–4 isolated from EtE were determined by spectral… 

Discovering the Major Antitussive, Expectorant, and Anti-Inflammatory Bioactive Constituents in Tussilago farfara L. Based on the Spectrum–Effect Relationship Combined with Chemometrics

TLDR
This study finds the main active compounds corresponding to the main pharmacodynamic effects of Farfarae Flos, the first time that spectrum–effect relationships in FF have been established using both raw and processed samples, which provides an experimental basis for further studies on the pharmacodynamic material basis.

Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects

TLDR
Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur along with six known compounds and exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.

Chemical compositions, pharmacological activities, quality control studies of Erycibes plants, and the development of their substitutes

TLDR
The rationale for use of Porana sinensis currently on the market is discussed and the current status of the chemical compositions, pharmacological activities, quality control studies, and the development of substitutes for Erycibes plants are summarized.

The extract of Acanthopanacis Cortex relieves the depression-like behavior and modulates IL-17 signaling in chronic mild stress-induced depressive mice

TLDR
The results revealed that Acanthopanacis Cortex showed great effects on anti-depression through immune inflammatory modulation, which will be useful for the development of clinical application of AC.

Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review

TLDR
It is evident that the efficient extraction of PAs requires further improvements or at least standardization of the extraction conditions, and LC-MS methods appear most suited.

Anti-inflammatory and anti-Candida effects of Brazilian organic propolis, a promising source of bioactive molecules and functional food.

TLDR
The results showed that BOP has strong anti-inflammatory effects and acts by reducing NF-кB activation, TNF-α release and neutrophil migration, and BOP6 exhibited antifungal activity on planktonic and biofilm cultures of Candida albicans and C. tropicalis.

Antioxidant and Mitochondria-Targeted Activity of Caffeoylquinic-Acid-Rich Fractions of Wormwood (Artemisia absinthium L.) and Silver Wormwood (Artemisia ludoviciana Nutt.)

TLDR
Findings show that caffeoylquinic acids might be beneficial as promising antioxidant and cytochrome-c-reducing agents for the modulation of mitochondria and treatment of various mitochondrial-pathway-associated pathologies.

References

SHOWING 1-10 OF 30 REFERENCES

Antitussive, expectorant and anti-inflammatory activities of different extracts from Exocarpium Citri grandis.

Metabolomic profiling of the antitussive and expectorant plant Tussilago farfara L. by nuclear magnetic resonance spectroscopy and multivariate data analysis.

Comparison of anti-bacterial activity of three types of di-O-caffeoylquinic acids in Lonicera japonica flowers based on microcalorimetry.

Antitussive Part of Flos Farfarae and Potentiating Part of Radix Asteris in Pair-drug of FF and RA

TLDR
The AE ofFF is more effective than its ethanol extracts, and the 90%insol-part of FF is the effective antitussive part.

[Studies on chemical constituents in the buds of Tussilago farfara].

  • Yu-feng LiuXiu-wei YangBin Wu
  • Chemistry, Medicine
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  • 2007
TLDR
Compounds 2-5 were isolated from the genus Tussilago farfara for the first time and structurally elucidated by NMR and MS evidences.

Cough, asthma, and cysteinyl-leukotrienes.

  • A. Niimi
  • Medicine, Biology
    Pulmonary pharmacology & therapeutics
  • 2013