Antitumour responses to flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid in immune deficient mice.

@article{Ching1992AntitumourRT,
  title={Antitumour responses to flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid in immune deficient mice.},
  author={L. M. Ching and Wayne R. Joseph and B. C. Baguley},
  journal={British Journal of Cancer},
  year={1992},
  volume={66},
  pages={128 - 130}
}
a candidate drug for clinical trial. FAA and 5,6-MeXAA share many properties with endotoxin: they induce the synthesis of tumour necrosis factor (TNF) (North & Havell, 1988; Mace et al., 1990) and stimulate the formation of nitric oxide, both in vitro (Drapier et al., 1988; Thomsen et al., 1990) and in vivo (Stuehr & Marletta, 1985; Thomsen et al., 1991). There are two main facets to the action of these agents. Firstly, by inducing TNF they promote the cessation of tumour blood flow and cell… CONTINUE READING

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Evidence for the production of nitric oxide by activated macrophages treated with the antitumour agents flavone-8-acetic acid and xanthenone4-acetic acid

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