Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay

@article{Aherne1996AntitumourEO,
  title={Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay},
  author={G. Aherne and A. Hardcastle and M. Valenti and A. Bryant and P. Rogers and G. Pettit and J. Srirangam and L. K{\`e}lland},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1996},
  volume={38},
  pages={225-232}
}
Abstract Dolastatins 10 and 15 are small peptides isolated from the marine sea hare Dolabella auricularia that have been shown to interact with tubulin. Their growth-inhibitory properties were compared using panels of human ovarian and colon-carcinoma cell lines. Both agents were very potent inhibitors of cell growth, with dolastatin 10 being an average of 9.1-fold more potent than dolastatin 15 [mean 50% inhibitory concentrations (IC50 values) 2.3×10–10 and 2.1×10–9M, respectively; P <0.05… Expand
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1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Role of P-glycoprotein in dolastatin 10 resistance.
Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15.
Preclinical pharmacology of the natural marine product dolastatin 10 (NSC 376128).
Radioimmunoassay of vinblastine and vincristine.
...
1
2
3
...