Antitumour action of 1,5-dihalogeno-, and 1, 2-4, 5-dianhydro-xylitol derivatives.


The antitumour action of some xylitol compounds possessing alkylating potency at 1 and 5 position of the sugar skeleton was investigated. Unlike the hexitol derivatives, bi-halogenated xylitols showed no antitumour action. The modest therapeutic index of 1, 2-4,5-dianhydroxylitol on the NK/Ly ascites tumour could be substantially increased by the addition of a phenyl-benzoyl group at the 3 position. This latter compound appeared to be active against L1210 leukaemia, S-180, and Yoshida solid sarcoma; and furthermore, against metastasis formation of the Lewis lung tumour.

Cite this paper

@article{Jeney1984AntitumourAO, title={Antitumour action of 1,5-dihalogeno-, and 1, 2-4, 5-dianhydro-xylitol derivatives.}, author={Andr{\'a}s Jeney and L{\'a}szl{\'o} Kopper and K{\'a}roly Lapis and L Vidra and L{\'a}szl{\'o} Instit{\'o}ris}, journal={Anticancer research}, year={1984}, volume={4 1-2}, pages={23-5} }