Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines

  title={Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines},
  author={Samuel Troadec and M{\'e}lina Blairvacq and N. Oumata and H. Galons and L. Meijer and C. Berthou},
  journal={Journal of Biomedical Science},
  • Samuel Troadec, Mélina Blairvacq, +3 authors C. Berthou
  • Published 2015
  • Medicine
  • Journal of Biomedical Science
  • BackgroundAlthough Imatinib mesylate has revolutionized the treatment of chronic myeloid leukemia, some patients develop resistance with progression of leukemia. Alternative or additional targeting of signalling pathways deregulated in Bcr-Abl-driven chronic myeloid leukemia may provide a feasible option for improving clinical response and overcoming resistance.ResultsIn this study, we investigate ability of CR8 isomers (R-CR8 and S-CR8) and MR4, three derivatives of the cyclin-dependent… CONTINUE READING
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