Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients.

@article{Brandacher2006AntitumoralAO,
  title={Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients.},
  author={Gerald Brandacher and Christiana Winkler and Katharina Schroecksnadel and Raimund Margreiter and Dietmar Fuchs},
  journal={Current drug metabolism},
  year={2006},
  volume={7 6},
  pages={599-612}
}
Insufficient immunosurveillance is an important aspect in early tumorigenesis and in the pathogenesis of malignant disease. In the later course of cancer, the development of immunodeficiency is considered the major reason for disease progression and death. Within the anti-tumoral host defense reaction, Th1-type cytokine interferon-gamma (IFN-gamma) is of particular relevance. IFN-gamma stimulates several anti-proliferative and thus tumoricidal biochemical pathways in macrophages and other cells… CONTINUE READING

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