Antitumoral activity of flavone L-86-8275.

  title={Antitumoral activity of flavone L-86-8275.},
  author={Joerg Czech and Dietrich Hoffmann and Ramadas Naik and H. Sedlacek},
  journal={International journal of oncology},
  volume={6 1},
L 86-8275, a flavone of novel structure, was shown to be a kinase inhibitor and to possess surprising potent antiproliferative potency (IC50=0.1-0.15 mu M) on various tumor cell lines after long period of incubation. Short period of incubation was significantly less effective (IC50=133 mu M). In vitro L 86-8275 showed almost no cross-resistance on L 1210… CONTINUE READING