Antitumor tests of amygdalin in transplantable animal tumor systems

  title={Antitumor tests of amygdalin in transplantable animal tumor systems},
  author={C. Stock and G. Tarnowski and F. Schmid and D. Hutchison and M. Teller},
  journal={Journal of Surgical Oncology},
Except for oral administration, there was no grossly observed toxicity from carefully administered high doses of amygdalin in the experimental systems used. The compound in high doses was ineffective against the DMBA‐induced rat mammary carcinoma and the following transplanted experimental tumors: Sarcoma 180, plasma cell tumor LPC‐1, leukemia L1210, Mecca lymphosarcoma, Ridgway osteogenic sarcoma, sarcoma T241, mammary carcinoma E0771, Taper liver tumor, Ehrlich carcinoma (solid and ascites… Expand
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In a series of 6 experiments with CD8F1 mice with spontaneous mammary adenocarcinomas Sugiura noted by macrovisual observation with some histology an overall average of 21% of mice with lungExpand
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To the Editor.— Janardan D. Khandekar, MD, and Harlan Edelman in their article, "Studies of Amygdalin (Laetrile) Toxicity in Rodents" (242:169, 1979), reported lethality in rats from intraperitonealExpand
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Laetrile (amygdalin) is not as non‐toxic as claimed, particularly when ingested orally, and especially when taken with plant material high in β‐glucosidase. Expand
Studies of amygdalin (laetrile) toxicity in rodents.
Findings seriously question the use of amygdalin in clinical medicine under any circumstances and strongly suggested cyanide poisoning as the cause of death in Fischer 344 rats. Expand
Catalytic degradation of amygdalin by extracellular enzymes from Aspergillus niger
Abstract Amygdalin is a controversial anti-tumor natural product that has been used as an alternative cancer drug for many years. The anti-tumor mechanism and metabolism of amygdalin have been theExpand
An in vitro study of amygdalin alone and complexed with Se(IV), Au(III), Ru(III), and V(III) ions: Structure, morphology, and pharmacology
  • A. Adam
  • Chemistry
  • Journal of Molecular Structure
  • 2019
Abstract Amygdalin is a naturally occurring product and was considered to be a natural cancer cure; however, its anticancer effects remain highly controversial. Furthermore, the bioactivity ofExpand
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A beta-glucosidase in feline kidney that hydrolyzes amygdalin (laetrile).
A β-glucosidase has been demonstrated in cat, rat, and rabbit kidney tissue that catalyzes the hydrolytic cleavage of the terminal glucose residue of amygdalin ( Laetrile-β-gentiobioside). Expand
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Special report on Laetrile: the NCI Laetrile Review. Results of the National Cancer Institute's retrospective Laetrile analysis.
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A spectrum of 8 tumors has been selected chiefly from 35 transplantable animal tumors used previously for chemotherapeutic studies at Sloan-Kettering Institute based on the sensitivity of the tumors to groups of standard antitumor drugs and on the biologic characteristics of these tumors. Expand
Chemotherapeutic studies on a new transplantable mouse liver tumor (Taper liver tumor).
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Failure of amygdalin to arrest B16 melanoma and BW5147 AKR leukemia.
Parenteral amygdalin was found to be ineffective in C57BL/6 mice with B16 melanoma and in AKR mice with BW5147 lymphatic leukemia, in doses ranging from 50 to 5000 mg/kg.
Effects of 17α-Thioestradiol, 2 Estradiol Analogs, and 2 Androgens on 7, 12-Dimethylbenz[a]anthracene-induced Rat Mammary Tumors
A thiol analog of estradiol was tested for antitumor activity in the 7, 12-dimenthylbenz( a )anthracene-induced mammary tumor-rat experimental chemotherapy system and the largest proportion of complete remissions of all tumors in each rat was produced by 17β-estradiol. Expand