Antitumor tests of amygdalin in spontaneous animal tumor systems

@article{Stock1978AntitumorTO,
  title={Antitumor tests of amygdalin in spontaneous animal tumor systems},
  author={C. Chester Stock and Daniel S. Martin and Kanematsu Sugiura and Ruth A. Fugmann and I M Mountain and Elisabeth Stockert and Franz A. Schmid and George S. Tarnowski},
  journal={Journal of Surgical Oncology},
  year={1978},
  volume={10}
}
In a series of 6 experiments with CD8F1 mice with spontaneous mammary adenocarcinomas Sugiura noted by macrovisual observation with some histology an overall average of 21% of mice with lung metastases when treated with 1,000–2,000 mg/kg/day of amygdalin compared with 90% of the control mice. The significance attributed to those early observations is seriously challenged by the negative findings of 3 independent investigators, by 2 out of 3 negative cooperative experiments in which Sugiura… 

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Amygdalin, a cyanogenic glycoside mostly found in the bitter almond kernel, plays an important role in conventional and modern medicine applications and was isolated with chromatographic purification methods and recrystallization.

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The original theory in the 1920s on the mode of action of Laetrile is described along with the research that followed in light of this theory, and the legal and socioeconomic implications are examined.

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Antitumor tests of amygdalin in transplantable animal tumor systems

TLDR
Amygdalin did not noticeably influence the toxicity or impair the efficacy of these chemotherapeutic agents in their respective systems: Cytosine arabinoside, methotrexate, cytoxan, or 5‐fluorouracil in L1210; the latter two in LPC‐1.

Metastatic incidence of a spontaneous murine mammary adenocarcinoma.

TLDR
A lung bioassay method was developed that demonstrated that mammary adenocarcinomas appearing spontaneously in BALB/c × DBA/8F1 female mice, as well as first-generation transplants of the tumors, gave rise to secondary pulmonary tumors, and the incidence of lung metastases was found to correlate with the size of the primary tumor.

Accurate identification of experimental pulmonary metastases.

  • H. Wexler
  • Medicine
    Journal of the National Cancer Institute
  • 1966