Antitumor tests of amygdalin in spontaneous animal tumor systems

@article{Stock1978AntitumorTO,
  title={Antitumor tests of amygdalin in spontaneous animal tumor systems},
  author={C. Chester Stock and D. S. Martin and Kanematsu Sugiura and Ruth A. Fugmann and I M Mountain and Elisabeth Stockert and Franz A. Schmid and George S. Tarnowski},
  journal={Journal of Surgical Oncology},
  year={1978},
  volume={10}
}
In a series of 6 experiments with CD8F1 mice with spontaneous mammary adenocarcinomas Sugiura noted by macrovisual observation with some histology an overall average of 21% of mice with lung metastases when treated with 1,000–2,000 mg/kg/day of amygdalin compared with 90% of the control mice. The significance attributed to those early observations is seriously challenged by the negative findings of 3 independent investigators, by 2 out of 3 negative cooperative experiments in which Sugiura… Expand
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Antitumor tests of amygdalin in transplantable animal tumor systems
TLDR
Amygdalin did not noticeably influence the toxicity or impair the efficacy of these chemotherapeutic agents in their respective systems: Cytosine arabinoside, methotrexate, cytoxan, or 5‐fluorouracil in L1210; the latter two in LPC‐1. Expand
Metastatic incidence of a spontaneous murine mammary adenocarcinoma.
TLDR
A lung bioassay method was developed that demonstrated that mammary adenocarcinomas appearing spontaneously in BALB/c × DBA/8F1 female mice, as well as first-generation transplants of the tumors, gave rise to secondary pulmonary tumors, and the incidence of lung metastases was found to correlate with the size of the primary tumor. Expand
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