Antitumor tests of amygdalin in spontaneous animal tumor systems

  title={Antitumor tests of amygdalin in spontaneous animal tumor systems},
  author={C. Chester Stock and D. S. Martin and Kanematsu Sugiura and Ruth A. Fugmann and I M Mountain and Elisabeth Stockert and Franz A. Schmid and George S. Tarnowski},
  journal={Journal of Surgical Oncology},
In a series of 6 experiments with CD8F1 mice with spontaneous mammary adenocarcinomas Sugiura noted by macrovisual observation with some histology an overall average of 21% of mice with lung metastases when treated with 1,000–2,000 mg/kg/day of amygdalin compared with 90% of the control mice. The significance attributed to those early observations is seriously challenged by the negative findings of 3 independent investigators, by 2 out of 3 negative cooperative experiments in which Sugiura… Expand
Studies of amygdalin (laetrile) toxicity in rodents.
Findings seriously question the use of amygdalin in clinical medicine under any circumstances and strongly suggested cyanide poisoning as the cause of death in Fischer 344 rats. Expand
Antitumor Action of Amygdalin on Human Breast Cancer Cells by Selective Sensitization to Oxidative Stress
Data support a mechanism of amygdalin antitumor action against breast cancer cells based on the induction of oxidative stress, which is able to reduce the growth of both cells, in concentration and time-dependent manners. Expand
Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro.
Amygdalin dose-dependently diminished tumor cell growth with maximum effects at 10mg/ml and merits further evaluation for therapeutic purposes. Expand
The case against laetrile. The fraudulent cancer remedy
Laetrile (amygdalin) is not as non‐toxic as claimed, particularly when ingested orally, and especially when taken with plant material high in β‐glucosidase. Expand
Amygdalin, quackery or cure?
No convincing evidence showing that amygdalin induces rapid, distinct tumor regression in cancer patients, particularly in those with late-stage disease, is apparent, however, there is also no evidence that purified Amygdalin, administered in "therapeutic" dosage, causes toxicity. Expand
Amygdalin - A pharmacological and toxicological review.
This paper systematically reviewed the pharmacology and toxicology of amygdalin and provided comprehensive information on this compound, suggesting that this compound presented pharmacological activities of anti-tumor, anti-fibrotic,Anti-inflammatory, analgesic, immunomodulatory, anti -atherosclerosis, ameliorating digestive system and reproductive system, improving neurodegeneration and myocardial hypertrophy, as well as reducing blood glucose. Expand
A beta-glucosidase in feline kidney that hydrolyzes amygdalin (laetrile).
A β-glucosidase has been demonstrated in cat, rat, and rabbit kidney tissue that catalyzes the hydrolytic cleavage of the terminal glucose residue of amygdalin ( Laetrile-β-gentiobioside). Expand
Special report on Laetrile: the NCI Laetrile Review. Results of the National Cancer Institute's retrospective Laetrile analysis.
A retrospective analysis of Laetrile treatment undertook in response to widespread public interest allowed no definite conclusions supporting the anti-cancer activity of Laetsrile. Expand
Amygdalin: Nutzen oder Risiko?
Die Komplementar- and Alternativmedizin (CAM) ist oftmals in die Behandlung von Tumorerkrankungen eingebunden anders als naturliches Heilmittel, gegner hingegen verneinen diese Eigenschaft und warnen vor toxischen Nebeneffekten. Expand
Laetrile--an overview.
The original theory in the 1920s on the mode of action of Laetrile is described along with the research that followed in light of this theory, and the legal and socioeconomic implications are examined. Expand


Antitumor tests of amygdalin in transplantable animal tumor systems
Amygdalin did not noticeably influence the toxicity or impair the efficacy of these chemotherapeutic agents in their respective systems: Cytosine arabinoside, methotrexate, cytoxan, or 5‐fluorouracil in L1210; the latter two in LPC‐1. Expand
Metastatic incidence of a spontaneous murine mammary adenocarcinoma.
A lung bioassay method was developed that demonstrated that mammary adenocarcinomas appearing spontaneously in BALB/c × DBA/8F1 female mice, as well as first-generation transplants of the tumors, gave rise to secondary pulmonary tumors, and the incidence of lung metastases was found to correlate with the size of the primary tumor. Expand
Accurate identification of experimental pulmonary metastases.
  • H. Wexler
  • Biology, Medicine
  • Journal of the National Cancer Institute
  • 1966