Antitumor necrosis factor-alpha therapy and potential cancer inhibition.

Tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of cancer, mainly in the context of chronic inflammation. Recent publications, however, have reported an increased risk of lymphoma in rheumatoid arthritis patients treated with immunomodulatory TNF-alpha blockers. To assess the role of TNF-alpha in neoplasia, a review of TNF… CONTINUE READING