Antitumor immunity and cancer stem cells.

  title={Antitumor immunity and cancer stem cells.},
  author={Tobias Schatton and M H Frank},
  journal={Annals of the New York Academy of Sciences},
Self-renewing cancer stem cells (CSC) capable of spawning more differentiated tumor cell progeny are required for tumorigenesis and neoplastic progression of leukemias and several solid cancers. The mechanisms by which CSC cause tumor initiation and growth are currently unknown. Recent findings that suggest a negative correlation between degrees of host immunocompetence and rates of cancer development raise the possibility that only a restricted minority of malignant cells, namely CSC, may… CONTINUE READING
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