Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells.

@article{Xin2005AntitumorIR,
  title={Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells.},
  author={Hong Xin and Toshiaki Kikuchi and Sita Andarini and Shinya Ohkouchi and Takuji Suzuki and Toshihiro Nukiwa and Huqun and Koichi Hagiwara and T. Honjo and Yasuo Saijo},
  journal={European journal of immunology},
  year={2005},
  volume={35 5},
  pages={1371-80}
}
The CX3C chemokine fractalkine (CX3CL1) exists as both a membrane-bound form promoting firm cell-cell adhesion and a soluble form chemoattracting leukocytes expressing its receptor CX3CR1. When adenoviral vector expressing mouse fractalkine (AdFKN) was transduced to the tumor cells, fractalkine was expressed as both membrane-bound form on the tumor cells and soluble form in the supernatant in vitro. Intratumoral injection of AdFKN (1 x 10(9)PFU/tumor) into C26 and B16F10 tumors resulted in… CONTINUE READING

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