Antitumor evaluation and multiple analysis on different extracted fractions of the root of Cynanchum auriculatum Royle ex Wight.

  title={Antitumor evaluation and multiple analysis on different extracted fractions of the root of Cynanchum auriculatum Royle ex Wight.},
  author={Xin-jie Wang and Zhenlin Li and Xu-hui Lv and Q. Y. Zuo and Yan-min Zhao and Yong-fang Ding and She-ban Pu and Shi-hui Qian and Yun-Ru Peng},
  journal={Journal of separation science},
  volume={40 15},
The root of Cynanchum auriculatum (C. auriculatum) Royle ex Wight has been shown to possess various pharmacological effects and has recently attracted much attention with respect to its potential role in antitumor activity. The C-21 steroidal glycosides are commonly accepted as the major active ingredients of C. auriculatum. In this study, the antitumor abilities of different extracted fractions of the root bark and the root tuber of C. auriculatum were investigated by using a 3-(4,5… 

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Total C-21 Steroidal Glycosides From Baishouwu Ameliorate Hepatic and Renal Fibrosis by Regulating IL-1β/MyD88 Inflammation Signaling

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Baishouwu Extract Suppresses the Development of Hepatocellular Carcinoma via TLR4/MyD88/NF-κB Pathway

Baishouwu extract exhibited potent effect on the development of HCC by altering TLR4/MyD88/ NF-κB signaling pathway in the sequence of hepatic inflammation-fibrosis-cancer, which provided novel insights into the mechanism of Baishou Wu extract as a candidate for the pretreatment of H CC in the future.



Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight.

Antitumor activity of crude extract and fractions from root tuber of Cynanchum auriculatum Royle ex Wight

Among the five samples, fraction E was noted to be of the highest antitumor activity and exhibited cytotoxic activity on human tumor cell lines K562, SHG44, HCT‐8, A549, PC3, in vitro and inhibition in mouse implanted sarcoma S180, in vivo.

Studies on The Anti-tumor Activity of C-21 Steroidal Glycosides in Baishouwu

CGB show significant antitumor effect in vitro and in vivo, and it also show moderate effect of inhibiting vascular growth in tumor tissues.

Studies on in vitro antitumor activity of total steroidal glycoside from the root of Cynanchum auriculatum

In vitro cytotoxicity of total steroidal glycoside from the root of Cynanchum auriculatum Royle ex Wight was studied and showed that CG exhibited potent cytotoxic effect on all four solid tumor cells lines in a concentration-dependent manner.

[Chemical Constituents of Cynanchum auriculatum].

Compounds 3, 5 and 6 - 9 are isolated from Cynanchum auriculatum for the first time on the basis of spectral analysis.

A C21-Steroidal Glycoside Isolated from the Roots of Cynanchum auriculatum Induces Cell Cycle Arrest and Apoptosis in Human Gastric Cancer SGC-7901 Cells

In conclusion, CGII inhibits cell growth of human gastric cancer cells by inducing G1 phase cell cycle arrest and caspase-dependent apoptosis cascades.

Influence of general steroidal glycosides from Radix Cynanchi Auriculati combined with cyclophosphamide on immunity in mice with tumor

General steroidal glycosides from Radix Cynanchi Auriculati combined with cyclophosphamide can improve cell immunity and humoral immunity in mice after chemotherapy and reduce the toxicity of common chemotherapeutic drugs.

[Effect of C21 steroidal glycoside from root of Cynanchum auriculatum on D-galactose induced aging model mice].

It is demonstrated that CSG can antagonize free radical injury, increase the SOD activity and decrease the MDA content of serum, heart, liver and brain in D-gal aging mice, and increase the telomerase activity in serum and heart tissues but not in Liver and brain tissue.

[Chemical constituents in the root of Cynanchum auriculatum].

Compounds I-IV are isolated from this plant for the first time and identified as taraxasterol acetate, succinic acid, betulinic acid, and wilfoside KIN.