Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells.

@article{Do2013AntitumorEO,
  title={Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells.},
  author={Minh Truong Do and Hyung Gyun Kim and Jae ho Choi and Tilak Khanal and Bong Hwan Park and Thu Phương Trần and Tae Cheon Jeong and Hye Gwang Jeong},
  journal={Food chemistry},
  year={2013},
  volume={141 3},
  pages={
          2591-9
        }
}
Piperine is a bioactive component of black pepper, Piper nigrum Linn, commonly used for daily consumption and in traditional medicine. Here, the molecular mechanisms by which piperine exerts antitumor effects in HER2-overexpressing breast cancer cells was investigated. The results showed that piperine strongly inhibited proliferation and induced apoptosis through caspase-3 activation and PARP cleavage. Furthermore, piperine inhibited HER2 gene expression at the transcriptional level. Blockade… Expand
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