Antitumor efficacy induced by a B16F10 tumor cell vaccine treated with mitoxantrone alone or in combination with reserpine and verapamil in mice.

@article{He2011AntitumorEI,
  title={Antitumor efficacy induced by a B16F10 tumor cell vaccine treated with mitoxantrone alone or in combination with reserpine and verapamil in mice.},
  author={Xiangfeng He and Jing Wang and Jun Dou and Fangliu Yu and Kai Yong Cai and Xiaoli Li and Hongyi Zhang and Ning Gu},
  journal={Experimental and therapeutic medicine},
  year={2011},
  volume={2 5},
  pages={911-916}
}
An apoptotic tumor cell serves as a potential potent trigger for the initiation of naturally occurring tumor immunity. In the present study, a B16F10 tumor cell vaccine treated with mitoxantrone (MIT) was developed, and its antitumor effect on mice was evaluated. The results indicated that the B16F10 tumor cell vaccine treated with MIT alone or in combination with reserpine (RP) and verapamil (VP) for 12 h triggered apoptosis, and that the expression of CD80, the MHC II class molecule, NKG2D… CONTINUE READING

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