Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: a new class of potential antineoplastic agents

@article{Mukherjee2009AntitumorEA,
  title={Antitumor efficacy and apoptotic activity of substituted chloroalkyl 1H-benz[de]isoquinoline-1,3-diones: a new class of potential antineoplastic agents},
  author={Asama Mukherjee and S Chakraborty Hazra and Sushanta Dutta and Shanmugavel Muthiah and Dilip Manikrao Mondhe and Parduman Raj Sharma and Shashank Kumar Singh and Ajit Kumar Saxena and Gulam Nabi Qazi and Utpal Sanyal},
  journal={Investigational New Drugs},
  year={2009},
  volume={29},
  pages={434-442}
}
A series of ten chloroalkyl 1H-benz[de]isoquinoline-1,3-diones (naphthalimides) were synthesized and evaluated for antitumor activity. Amongst them, new compounds 2d and 2i carrying a 6-NO2 substituent in the aromatic portion of the molecule possessed significant antineoplastic activity. The most active compound 2i had elicited significant cytotoxicity in 15 human tumor cell lines namely Leukemia: MOLT-4, HL-60; Lymphoma: U-937; Colon: 502713, HT-29, SW-620, HCT-15, COLO-205; Liver: Hep-2… CONTINUE READING
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