Antitumor effects of recombinant BCG and interleukin-12 DNA vaccines on xenografted murine bladder cancer.

@article{Yu2004AntitumorEO,
  title={Antitumor effects of recombinant BCG and interleukin-12 DNA vaccines on xenografted murine bladder cancer.},
  author={Dah-Shyong Yu and Chi-Feng Lee and D Hsieh and S Chang},
  journal={Urology},
  year={2004},
  volume={63 3},
  pages={596-601}
}
OBJECTIVES To evaluate the antitumor effects of recombinant bacille Calmette-Guérin (BCG) DNA (multi-rBCG) and murine interleukin-12 DNA (mIL-12) vaccines on xenografted MBT-2 murine bladder tumors. METHODS Treatment with combined multi-rBCG and mIL-12 was examined in syngeneic C3H/HeN mice and athymic nude mice. The delivery efficiency of multi-rBCG expression was detected by flow cytometry. Inhibition of tumor growth was monitored, and antitumor effects were evaluated after one dose of… CONTINUE READING