Antitumor effects of granulocyte-macrophage colony-stimulating factor production by melanoma cells.

@article{Armstrong1996AntitumorEO,
  title={Antitumor effects of granulocyte-macrophage colony-stimulating factor production by melanoma cells.},
  author={Cheryl A. Armstrong and Rafael Botella and Tamara Galloway and Nevin R Murray and J M Kramp and In Sun Song and John C. Ansel},
  journal={Cancer research},
  year={1996},
  volume={56 9},
  pages={2191-8}
}
The use of immunomodulating gene therapy in the treatment of malignant disease is under intensive investigation. In this study, we examined the potential of melanoma-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) to inhibit melanoma progression in a murine model. The HGH18 murine melanoma cell line was transfected with the murine GM-CSF gene in a SV40 expression vector that resulted in melanoma clones that produced varying amounts of GM-CSF. Syngeneic mice inoculated s.c… CONTINUE READING

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