Antitumor effects of bis(ethyl)polyamine analogs on mammary tumor development in FVB/NTgN (MMTVneu) transgenic mice.

@article{Shah1999AntitumorEO,
  title={Antitumor effects of bis(ethyl)polyamine analogs on mammary tumor development in FVB/NTgN (MMTVneu) transgenic mice.},
  author={Nand K Shah and Tresa Remya Thomas Antony and Salim Haddad and Peter S. Amenta and Akira Shirahata and T J Thomas},
  journal={Cancer letters},
  year={1999},
  volume={146 1},
  pages={15-23}
}
We studied the therapeutic potential of two polyamine analogs on breast cancer using FVB/NTgN (MMTVneu), a transgenic mouse model with neu/erb-B2 oncogene overexpression. Treatment was initiated at 31 weeks of age with bis(ethyl)norspermine (BE333) and its higher homolog, BE3333 as i.p. injections once weekly. There was a 40% reduction in the average number of tumors per mouse in both treatment groups, by 10 weeks of treatment. BE3333-treated mice had 70-75% lower tumor volume than controls… CONTINUE READING