Antitumor effects of Isatin on human neuroblastoma cell line (SH-SY5Y) and the related mechanism.


The purpose of the study was to investigate the antitumor effects of Isatin and the related mechanism. Human neuroblastoma cells (SH-SY5Y) were exposed to Isatin at different concentrations for 48 h. Apoptotic features were demonstrated by means of nuclei staining with Hoechst 33258 and flow cytometry with propidium iodide (PI). Expressions of Bcl-2, Bax… (More)
DOI: 10.1016/j.ejphar.2008.04.061