Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa.

@article{GuimaresFerreira2007AntitumorEI,
  title={Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa.},
  author={Carla A Guimar{\~a}es-Ferreira and Elaine Guadelupe Rodrigues and Renato Arruda Mortara and Hamilton Cabral and Fabiana A Serrano and Ricardo Ribeiro-dos-Santos and Luiz Henrique Ramos Travassos},
  journal={Neoplasia},
  year={2007},
  volume={9 9},
  pages={
          723-33
        }
}
In the present work, the antitumor effect of fastuosain, a cysteine proteinase from Bromelia fastuosa, was investigated. In the intravenous model of lung colonization in C57Bl/6 mice, fastuosain and bromelain injected intraperitoneally were protective, and very few nodules of B16F10-Nex2 melanoma cells were detected. Tumor cells treated with fastuosain showed reduced expression of CD44 and decreased invasion through Matrigel, lost their cytoplasmic extensions and substrate adherence, and became… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS