Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo

@article{Zhu2012AntitumorEO,
  title={Antitumor effect of the mTOR inhibitor everolimus in combination with trastuzumab on human breast cancer stem cells in vitro and in vivo},
  author={Yuanxi Zhu and Xiaobei Zhang and Yan Liu and Sheng Zhang and Jingjing Liu and Yi Ma and Jin Zhang},
  journal={Tumor Biology},
  year={2012},
  volume={33},
  pages={1349-1362}
}
This study evaluated the effects of a mammalian target of mTOR inhibitor everolimus alone or in combination with trastuzumab on stem cells from HER2-overexpressing primary breast cancer cells and the BT474 breast cancer cell line in vitro and in vivo. For the in vitro studies, we sorted ESA+CD44+CD24−/low cells as stem cells from primary breast cancer cells and BT474 cells using flow cytometry. The MTT assay was used to quantify the inhibitory effect of the drugs on total cells and stem cells… CONTINUE READING
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