Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.

  title={Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.},
  author={Tatsuo Okui and Tsuyoshi Shimo and Takuya Fukazawa and Naito Kurio and N M Hassan and Tatsuki Honami and Munenori Takaoka and Yoshio Naomoto and Akira Sasaki},
  journal={Molecular cancer therapeutics},
  volume={9 11},
The mammalian target of rapamycin (mTOR) is engaged in the molecular pathogenesis of oral squamous cell carcinoma, which frequently invades the maxilla or the mandible. However, the effects of a mTOR inhibitor on bone destruction associated with oral squamous cell carcinoma are still unclear. In this study, we investigated the antitumor effect of temsirolimus-mediated mTOR inhibition against advanced oral squamous cell carcinoma. Temsirolimus inhibited the proliferation and migration of HSC-2… CONTINUE READING


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