Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C.

@article{Ito2003AntitumorEO,
  title={Antitumor effect of resveratrol oligomers against human cancer cell lines and the molecular mechanism of apoptosis induced by vaticanol C.},
  author={T. Ito and Y. Akao and H. Yi and K. Ohguchi and K. Matsumoto and T. Tanaka and Munekazu Iinuma and Y. Nozawa},
  journal={Carcinogenesis},
  year={2003},
  volume={24 9},
  pages={
          1489-97
        }
}
  • T. Ito, Y. Akao, +5 authors Y. Nozawa
  • Published 2003
  • Biology, Medicine
  • Carcinogenesis
  • Twenty resveratrol (3,5,4'-trihydroxystilbene) (Res) derivatives, which were isolated from stem bark of Vatica rassak (Dipterocarpaceae), were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. Among them, seven compounds displayed marked cytotoxicity. Vaticanol C (Vat C) as a major component induced a considerable cytotoxicity in all cell lines tested and exhibited growth suppression in colon cancer cell lines at low dose. Vat C caused two cell lines (SW480 and HL60… CONTINUE READING
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