Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal.

@article{Chuang2011AntitumorEO,
  title={Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal.},
  author={Hui-Yen Chuang and Ya-Fang Chang and Jeng-Jong Hwang},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2011},
  volume={65 4},
  pages={286-92}
}
We established a HT-29/tk-luc human colorectal carcinoma-bearing animal model for the study of the inhibition effect and mechanism of orlistat, a fatty acid synthase (FASN) inhibitor. The results showed that orlistat caused cell cycle arrest at G1 phase, and triggered apoptosis through caspase-3 activation. The tumor inhibition effect of orlistat may also due to the inhibition of fatty acid synthesis without altering FASN activity. The tumor size of orlistat-treated mice in vivo was… CONTINUE READING

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