Antitumor effect of metformin in esophageal cancer: in vitro study.

@article{Kobayashi2013AntitumorEO,
  title={Antitumor effect of metformin in esophageal cancer: in vitro study.},
  author={Mitsuyoshi Kobayashi and Kiyohito Kato and Hisakazu Iwama and Shintarou Fujihara and Noriko Nishiyama and Shima Mimura and Yuka Toyota and Takako Nomura and Kei Nomura and Joji Tani and Hisaaki Miyoshi and Hideki Kobara and Hirohito Mori and Koji Murao and Tsutomu Masaki},
  journal={International journal of oncology},
  year={2013},
  volume={42 2},
  pages={
          517-24
        }
}
Recent studies suggest that metformin, which is a member of the biguanide family and commonly used as an oral anti-hyperglycemic agent, may reduce cancer risk and improve prognosis of numerous types of cancer. However, the mechanisms underlying the antitumor effect of metformin on esophageal cancer remain unknown. The goal of the present study was to evaluate the effects of metformin on the proliferation of human ESCC in vitro, and to study changes in the expression profile of microRNAs (miRNAs… CONTINUE READING

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