Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice

@article{Murosaki2000AntitumorEO,
  title={Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice},
  author={Shinji Murosaki and Koutarou Muroyama and Yoshihiro Yamamoto and Yasunobu Yoshikai},
  journal={Cancer Immunology, Immunotherapy},
  year={2000},
  volume={49},
  pages={157-164}
}
 We have previously reported that heat-killed Lactobacillus plantarum L-137 is a potent inducer of interleukin-12 (IL-12) in vivo as well as in vitro in mice. In order to develop effective usage of L. plantarum L-137 for tumor immunotherapy, we examined its antitumor effect against DBA/2 mice inoculated with syngenic P388D1 tumor cells in different treatment schedules. Daily injection of L. plantarum L-137 from the day of tumor inoculation induced a steep increase in plasma IL-12 only after the… CONTINUE READING

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