Antitumor effect of green tea polyphenol epigallocatechin-3-gallate in ovarian carcinoma cells: evidence for the endothelin-1 as a potential target.

@article{Spinella2006AntitumorEO,
  title={Antitumor effect of green tea polyphenol epigallocatechin-3-gallate in ovarian carcinoma cells: evidence for the endothelin-1 as a potential target.},
  author={Francesca M. Spinella and Laura Rosan{\`o} and Samantha Decandia and Valeriana Di Castro and Adriana Albini and Giacomo Elia and Pier Giorgio Natali and Anna Bagnato},
  journal={Experimental biology and medicine},
  year={2006},
  volume={231 6},
  pages={1123-7}
}
The green tea polyphenol, epigallocatechin-3-gallate (EGCG), has been shown to prevent cancer; however, a precise mechanism responsible for tumor growth inhibition has not yet been clearly described. The endothelin (ET) A receptor (ET(A)R)/ET-1 autocrine pathway is overexpressed in ovarian carcinoma and triggers tumor growth, neoangiogenesis, and invasion. These latter tumor-promoting effects are mediated through the activation of cyclooxygenase (COX)-1- and COX-2-dependent pathways by ET-1. In… CONTINUE READING

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