Antitumor effect of an HER2-specific antibody-toxin fusion protein on human prostate cancer cells.

@article{Wang2001AntitumorEO,
  title={Antitumor effect of an HER2-specific antibody-toxin fusion protein on human prostate cancer cells.},
  author={Lei E. Wang and Bolin Liu and Mathias Schmidt and Yi Lu and Winfried S. Wels and Zhen Xing Fan},
  journal={The Prostate},
  year={2001},
  volume={47 1},
  pages={21-8}
}
BACKGROUND HER2/neu has been implicated in the oncogenesis of human prostate cancer. Clinical studies have suggested that overexpression of HER2 may be one of the indicators of poor prognosis in prostate cancer patients. METHODS We used Western blot analysis to examine the expression of HER2 in a panel of established human prostate cancer cell lines and used an MTT assay to evaluate the cytotoxicity on these cells of a recombinant fusion protein consisting of an HER2-specific single-chain… CONTINUE READING
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