Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.

@article{Kang2006AntitumorEO,
  title={Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.},
  author={Sokbom Kang and Heidi T Cho and S. Devi and Zhaobin Zhang and Daniel Escuin and Zhongxing Liang and Hui Mao and Daniel J. Brat and Jeffrey L Olson and Jonathan W. Simons and Theresa M Lavallee and Paraskevi Giannakakou and Erwin G Van Meir and Hyunsuk Shim},
  journal={Cancer research},
  year={2006},
  volume={66 24},
  pages={
          11991-7
        }
}
Grade 4 malignant glioma (GBM) is a fatal disease despite aggressive surgical and adjuvant therapies. The hallmark of GBM tumors is the presence of pseudopalisading necrosis and microvascular proliferation. These tumor cells are hypoxic and express hypoxia-inducible factor-1 (HIF-1), a prosurvival transcription factor that promotes formation of neovasculature through activation of target genes, such as vascular endothelial growth factor. Here, we evaluated whether 2-methoxyestradiol, a… CONTINUE READING

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