Antitumor characteristics of methoxypolyethylene glycol-poly(DL-lactic acid) nanoparticles containing camptothecin.

@article{Miura2004AntitumorCO,
  title={Antitumor characteristics of methoxypolyethylene glycol-poly(DL-lactic acid) nanoparticles containing camptothecin.},
  author={Hidetaka Miura and Hiraku Onishi and Masanaho Sasatsu and Yoshiharu Machida},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2004},
  volume={97 1},
  pages={
          101-13
        }
}
The novel nanoparticles (CPT-NP) were prepared by the solvent evaporation method using methoxypolyethylene glycol-poly(DL-lactic acid) block copolymer as a matrix and camptothecin (CPT) as an antitumor agent, and the antitumor characteristics were examined in vitro and in vivo. The mean diameter of CPT-NP was approximately 250 nm. The drug release from CPT-NP in phosphate-buffered saline, pH 7.4, depended on the particle concentration; in the diluted condition, the initial rapid release was… Expand
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