Antitumor and toxicity evaluation of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes

@article{Rahman1986AntitumorAT,
  title={Antitumor and toxicity evaluation of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes},
  author={Aquilur Rahman and Angelo Fumagalli and Brunella Barbieri and Philips S. Schein and Anna Maria Casazza},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1986},
  volume={16},
  pages={22-27}
}
The antitumor activity of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes was evaluated in P388 ascitic leukemia, disseminated Gross leukemia, and advanced mammary carcinoma. In P388 leukemia, free drug and drug entrapped in liposomes demonstrated equivalent antitumor activity at doses of 2.2 and 4.4 mg/kg, demonstrating 52% and 69% ILS (increase in life-span), respectively. Free doxorubicin at a dose of 10 mg/kg was superior, producing a 185% ILS against 82% with liposomal… CONTINUE READING
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Liposome targeting in vivo: problems and opportunities

  • G Poste
  • Biol Cell
  • 1983
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