Antitumor and immunomodulatory activity of a water-soluble low molecular weight polysaccharide from Schisandra chinensis (Turcz.) Baill.

@article{Zhao2013AntitumorAI,
  title={Antitumor and immunomodulatory activity of a water-soluble low molecular weight polysaccharide from Schisandra chinensis (Turcz.) Baill.},
  author={Ting Zhao and Guanghua Mao and Riwen Mao and Ye Zou and Daheng Zheng and Weiwei Feng and Yuena Ren and Wei Wang and Wei Zheng and Jia L Song and Yuanqing Chen and Liuqing Yang and Xiang-yang Wu},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2013},
  volume={55},
  pages={609-16}
}
A water-soluble low molecular weight polysaccharide (SCPP11) was extracted and purified using DEAE-cellulose and Sephadex G-100 column from Schisandra chinensis (Turcz.) Baill. Its in vivo and in vitro antitumor and immunomodulatory activity were investigated. The results showed that SCPP11 with a molecular weight of 3.4×10(3)Da exhibited indirect cyctotoxic activity against tumor cells in vitro, but could significantly inhibit the growth of Heps cells in vivo at dose of 50mg/kg, and its… CONTINUE READING
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