Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.

@article{Usami2008AntitumorA2,
  title={Antitumor agents. 261. 20(S)-protopanaxadiol and 20(s)-protopanaxatriol as antiangiogenic agents and total assignment of (1)H NMR spectra.},
  author={Yoshihide Usami and Yi-Nan Liu and A L Lin and Makio Shibano and Toshiyuki Akiyama and Hideji Itokawa and Susan Lynne Morris-Natschke and Kenneth F. Bastow and Ryoji Kasai and Kuo-Hsiung Lee},
  journal={Journal of natural products},
  year={2008},
  volume={71 3},
  pages={478-81}
}
Angiogenesis is a critical step in tumor progression and involves several steps including endothelial cell (EC) proliferation, migration, and matrix remodeling. We investigated the antiangiogenic effects of 20( S)-protopanaxadiol ( 1) and 20( S)-protopanaxatriol ( 2), the sapogenins of two major ginseng saponins, in an angiogenesis model of human umbilical vein endothelial cells (HUVECs). These compounds inhibited the proliferative activity of HUVECs in a dose-dependent manner and have… CONTINUE READING