Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.

@article{Ohtsu2002AntitumorA2,
  title={Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.},
  author={Hironori Ohtsu and Zhiyan Xiao and Junko Ishida and Masahiro Nagai and H Wang and Hideji Itokawa and C Su and Charles C-Y Shih and Tzuying Chiang and Eugene Chang and Yifen Lee and Meng-Yin Tsai and Chawnshang Chang and Kuo-Hsiung Lee},
  journal={Journal of medicinal chemistry},
  year={2002},
  volume={45 23},
  pages={5037-42}
}
A number of curcumin analogues were prepared and evaluated as potential androgen receptor antagonists against two human prostate cancer cell lines, PC-3 and DU-145, in the presence of androgen receptor (AR) and androgen receptor coactivator, ARA70. Compounds 4 [5-hydroxy-1,7-bis(3,4-dimethoxyphenyl)-1,4,6-heptatrien-3-one], 20 [5-hydroxy-1,7-bis[3-methoxy-4-(methoxycarbonylmethoxy)phenyl]-1,4,6-heptatrien-3-one], 22 [7-(4-hydroxy-3-methoxyphenyl)-4-[3-(4-hydroxy-3-methoxyphenyl)acryloyl]-5… CONTINUE READING