Antitumor agents. 134. New shiraiachrome-A- and calphostin-C-related perylene derivatives as cytotoxic and antiviral agents and inhibitors of protein kinase C.

@article{Wang1992AntitumorA1,
  title={Antitumor agents. 134. New shiraiachrome-A- and calphostin-C-related perylene derivatives as cytotoxic and antiviral agents and inhibitors of protein kinase C.},
  author={Hongbing Wang and Jing Xia Xie and Jessica J Chang and Kou M. Hwang and Stephen Y Liu and Lawrence M. Ballas and Jack B. Jiang and Kuo Hsiung Lee},
  journal={Journal of medicinal chemistry},
  year={1992},
  volume={35 15},
  pages={2717-21}
}
Shiraiachrome-A and -B have been isolated from the mycelium of the Chinese bamboo fungus Shiraia bambusicola as the cytotoxic principles. A series of new perylene derivatives (7-27) related to Shiraiachrome-A and -B as well as Calphostin-C have been synthesized and evaluated for their cytotoxicity, antiviral activity, and inhibitory activity against protein kinase C. The results indicated that 11 and 12 are potent cytotoxic agents against HCT-8, RPMI-7951, and TE-671 solid tumor cells, whereas… CONTINUE READING