Antitumor agents XXIX: Effects of eupahyssopin on nucleic acid, protein, anaerobic, and aerobic metabolism of Ehrlich ascites tumor cells.

@article{Hall1978AntitumorAX,
  title={Antitumor agents XXIX: Effects of eupahyssopin on nucleic acid, protein, anaerobic, and aerobic metabolism of Ehrlich ascites tumor cells.},
  author={Iris H. Hall and K. H. Lee and S A Eigebaly},
  journal={Journal of pharmaceutical sciences},
  year={1978},
  volume={67 9},
  pages={
          1232-5
        }
}
Abstract Evidence is presented that the antitumor agent eupahyssopin, a germacranolide, inhibits deoxyribonucleic acid, ribonucleic acid, protein, and cholesterol synthesis of Ehrlich ascites tumor cells in CF 1 male mice. Eupahyssopin appears to bind to nucleotide bases of deoxyribonucleic acid. The drug also inhibits deoxyribonucleic acid and messenger ribonucleic acid polymerase activities and, marginally, thymidylate synthetase activity. Template activity, as regulated by phosphorylation of… 
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Antitumor agents XXVII: Effects of helenalin on anaerobic and aerobic metabolism of Ehrlich ascites cells.

A number of enzymes of anaerobic and aerobic carbohydrate metabolism of Ehrlich ascites cells appear to be inhibited by helenalin, which supposedly can alkylate functional groups, e.g., sulfhydryl groups of these enzymes, by a rapid Michael-type addition.

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