Antitumor agents, 75. Synthesis of cytotoxic anthraquinones digiferruginol and morindaparvin-B.

@article{Chang1985AntitumorA7,
  title={Antitumor agents, 75. Synthesis of cytotoxic anthraquinones digiferruginol and morindaparvin-B.},
  author={P. Chang and K. Lee},
  journal={Journal of natural products},
  year={1985},
  volume={48 6},
  pages={
          948-51
        }
}
  • P. Chang, K. Lee
  • Published 1985
  • Chemistry, Medicine
  • Journal of natural products
A simple and efficient synthesis of digiferruginol (4) and morindaparvin-B (10) is described. Marschalk reaction of 1-hydroxyanthraquinone afforded 1-hydroxy-2-methylanthraquinone (2). Treatment of 2 with N-bromosuccinimide and benzoyl peroxide led to 1-hydroxy-2-bromomethylanthraquinone (3), which was converted to 4 with AgNO3 in quantitative yield. Methylation of 1,5-dihydroxyanthraquinone yielded a dimethyl ether (6), which was partially demethylated with boron trifluoride to a difluoroboron… Expand
16 Citations
A new anthraquinone from Morinda elliptica Ridl.
  • 6
Novel antitumor agents from higher plants
  • K. Lee
  • Chemistry, Medicine
  • Medicinal research reviews
  • 1999
  • 162
Establishment of cell suspension cultures of Morinda elliptica for the production of anthraquinones
  • 53
  • PDF
A review on plant-derived natural products and their analogs with anti-tumor activity
  • 45
  • PDF
...
1
2
...