Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters.

@article{Tengchaisri1998AntitumorAO,
  title={Antitumor activity of triptolide against cholangiocarcinoma growth in vitro and in hamsters.},
  author={Tasanee Tengchaisri and Runglawan Chawengkirttikul and Nattawan Rachaphaew and Vichai Reutrakul and R Sangsuwan and Stitaya Sirisinha},
  journal={Cancer letters},
  year={1998},
  volume={133 2},
  pages={169-75}
}
One of the diverse biological activities of triptolide, a diterpene from Tripterygium wilfordii, is its antitumor effect. We recently reported its in vitro cytotoxicity against several cultured tumor cell lines. Limited availability of purified fraction has prevented detailed investigation on its antitumor activity. In the present study, we showed by in vitro cytotoxicity assay and in vivo inhibition of tumor growth in hamsters that the triptolide was also highly effective against… CONTINUE READING
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