Antitumor activity of titanocene dichloride in xenografted human renal-cell carcinoma.

@article{KpfMaier1999AntitumorAO,
  title={Antitumor activity of titanocene dichloride in xenografted human renal-cell carcinoma.},
  author={Petra K{\"o}pf-Maier},
  journal={Anticancer research},
  year={1999},
  volume={19 1A},
  pages={493-504}
}
Titanocene dichloride [(C5H5)2TiCl2] is a new-developed organometallic antitumor agent which is currently being investigated in clinical trials of phases I and II. In the present study, it was tested for antitumor activity in human renal tumors either growing as monolayers in vitro or as xenografts in athymic mice. For comparison, approved cytostatic drugs (in vitro, vinblastine and 5-fluoro-2'-deoxyuridine; in vivo, cyclophosphamide, vinblastine, and 5-fluorouracil) were administered in vitro… CONTINUE READING