Antitumor activity of bis(diphenylphosphino)alkanes, their gold(I) coordination complexes, and related compounds.

@article{Mirabelli1987AntitumorAO,
  title={Antitumor activity of bis(diphenylphosphino)alkanes, their gold(I) coordination complexes, and related compounds.},
  author={Christopher K. Mirabelli and David T Hill and Leo F Faucette and Francis L. McCabe and G R Girard and Doug Bryan and Benjamin M Sutton and Joan O'Leary Bartus and Stanley T. Crooke and Randall K. Johnson},
  journal={Journal of medicinal chemistry},
  year={1987},
  volume={30 12},
  pages={
          2181-90
        }
}

• Christopher K. Mirabelli, David T Hill, +7 authors Randall K. Johnson
• Published 1987 in Journal of medicinal chemistry

Bisphosphines related to bis(diphenylphosphino)ethane (dppe) and their gold complexes are described that are active in a spectrum of transplantable tumor models. When administered ip on days 1-5 at its maximally tolerated dose (MTD) of 40 mumol/kg, dppe reproducibly gives 100% increase in life span (ILS) in mice bearing ip P388 leukemia. Coordination of chlorogold(I) to each phosphine in dppe gave a complex that had similar activity but at a much lower dose level than dppe; the MTD for the gold… CONTINUE READING

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